Axonal lesions in multiple sclerosis: an old story revisited

Axonal damage in acute multiple sclerosis lesions.

One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination, with myelin destruction and relative sparing of axons. On the other hand, it is widely accepted that axonal loss occurs in, and is responsible for, the permanent disability characterizing the later chronic progressive stage of the disease. In this study, we have used an antibody against amyloid precu...

Axonal transection in the lesions of multiple sclerosis.

BACKGROUND Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system and is the most common cause of neurologic disability in young adults. Despite antiinflammatory or immunosuppressive therapy, most patients have progressive neurologic deterioration that may reflect axonal loss. We conducted pathological studies of brain tissues to define the changes in axons in...

Extensive acute axonal damage in pediatric multiple sclerosis lesions.

OBJECTIVE Axonal damage occurs early in multiple sclerosis (MS) and contributes to the degree of clinical disability. Children with MS more often show disabling and polyfocal neurological symptoms at disease onset than adults with MS. Thus, axonal damage may differ between pediatric and adult MS patients. METHODS We analyzed axonal pathology in archival brain biopsy and autopsy samples from 1...

Janeway lesions: an old sign revisited.

A 20-year-old man presented with intermittent, high grade fever of 2 weeks’ duration and progressively worsening shortness of breath for the same period. On examination, he had tachycardia and pulsus bisferiens. In addition, he had multiple nontender, macular spots of varying sizes over hands and feet for the past 4 to 5 days (Figure 1A and 1B). His echocardiogram revealed severe aortic regurgi...

Axonal injury in multiple sclerosis.